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Ultrasound-bouncing bubbles help track bacteria in mice - Bacteria engineered with gas vesicles allow ultrasound to image microbes at higher resolutions and greater depths than before

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Wow this is super cool. Too bad they didn't show the ultrasound images of the mouse colon that the article mentioned.

Here, here! As weird as it might sound, I'd actually want to see that.

Original Poster2 points · 5 months ago

Bourdeau RW, Lee-Gosselin A, Lakshmanan A, Farhadi A, Kumar SR, Nety SP et al. (2018)

Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts. Nature 553 (7686):86-90. DOI: 10.1038/nature25021 PMID: 29300010.


Currently, the most popular method is to get bacteria to express fluorescent proteins and then track the microbes through their bioluminescence.

But bioluminescence-based techniques work at depths of only a few millimeters below the body’s surface, and their resolution degrades quickly with depth.

Mikhail G. Shapiro of Caltech and coworkers have now developed a new technique based on ultrasound imaging that improves imaging depth to more than 10 cm and substantially enhances spatial resolution (Nature 2018, DOI: 10.1038/nature25021).

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