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We now have a Wiki entry that goes into the history of Rule 7, it's current definition, and an explanation on how to search this sub effectively. And in case people don't feel like reading the whole thing...


  1. There are no exceptions to Rule 7. Whether you're on mobile, or search is down, or you don't feel like searching, or mods are [expletive deleted], you still need to search.

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Edit notes: added the bit about including search results when contesting.

  • 1) Prions can arise spontaneously (very rare, but over the course of billion years doesn't matter, will happen).
  • 2) Prions are more difficult than regular proteins to denature.
  • 3) If they're in a living system, AFAIK impossible to eradicate without destroying that organism.
  • 4) Can be passed down to progeny.
  • 5) Can be passed via predator/scavenger -> prey relationships, basically any non-sapient ecological consumption/recycling system.
  • 6) Can even be passed via blood exposure/touch, and other non-consumption means (rare).
  • 7) They can lie latent for upwards of 50 years*.
  • 8) Determining a set of organisms has the disease is hard, and the only way to eradicate it is to eliminate all of the carriers (not something a non-intelligent, non-herding species can do?).
  • 9) 1 in 100 trillion chance of spontaneously happening means it happened within the first couple 100 years of multi-cellular life?

Given all of that, why didn't a prion spontaneously occur in the past once we had multi-cellular organisms (or sexually reproducing organisms), infect a living system, and become prevalent everywhere?

I've seen some disease modeling, and given the above constraints, it implies that there must be some mechanism holding back prions' spread. What would such a mechanism have to look like - mathematically speaking?

. * A large number of British (1 in 2,000) have unexpressed prions currently, due to Mad Cow outbreak

It's been humid in my area for a couple days, and my house dehumidifier has been emptied a few times which got me wondering about the water quality in the tank. Is there enough water content in the air to pull liquid water out in places where people don't have enough water to drink? Also, how would the quality and pureness rate? If the machine was kept clean would the water be drinkable?


This may seem obvious, but what are some of the tell-tale signs that a fossil is from a new species rather than just a smaller/larger/different sex/big boned/deformed member of an already discovered extinct species? I’m thinking mostly of fossilized bones and dinosaurs. I’m always amazed that scientists have discovered so many distinct species when many of the dinosaurs I read about seem to look so similar.


I just submitted a rebate and it stated it would take at least 4-6 weeks for me to receive it. What gives? I figured submitting these things online now would speed up the process over the old school snail mail method.


With all the possible appeals and everything, do the exorbitant multi million dollar damages by the tobacco industry or the pharmaceutical companies get paid in full, and how long does it take?


I just realized there are like 10+ websites that showcase my addresses from the past ten years and it really freaked me out. I see that there are long and complicated ways to opt-out, but I also see that “public records” are legally out there and resurface over and over on these sites. Can you buy real protection especially if you have millions of potential stalkers?


Why do some companies like TJX (which owns all T.J. Maxx, Marshalls and Home Goods stores) have the same merchandise in multiple different named stores, they all sell the same stuff. Some of these stores are all in the same shopping center, doesn't is cost more money to rent 3 stores in the same shopping center than just one larger one? Isn't running 3 stores with all different names costing them more money in over-head?


Like why can you set kerosene, gasoline and alcool on fire but not milk and orange juice?


I was always taught that if I happen to be driving and a tornado forms I should park my car to the side of the road and wait it out. Why would it make a difference if I’m driving? What’s safer about waiting for the storm to pass, rather than driving away and getting to safety? Asking because I’m currently in this situation, thinking I should drive the 5 miles I am away from my house.

Edit: Went ahead and hauled butt home, and about halfway there a some debris went straight past my windshield, so I’d probably say it’s safer to just stay put next time. Thanks for all the responses!


I'm sick, and I basically take cough drops religiously because I use my voice a lot. And Halls works incredibly (like they should). What causes them to work well? Is it just the recipe?


So i was listening to some music, and it autoplay'd on this. I was listening to it on 1.25 speed, because i left it on, and the piano at the beginning sounded flat and sharp. why?


Recently Pearl Jam had to cancel a concert in London because Eddie Vedder lost his voice. The music industry is incredibly complex, so what happens financially speaking? I'm sure Eddie's voice is insured for a lot of money, but what happens with the concert promoters, venue, ticket sales companies (primary and secondary market), etc...?

I assume Pearl Jam is liable to cover the losses of the companies involved, and much of that (if not all) can be covered by insurance, but I have no idea how money flows in large concert tours such as this.


I’ve been watching a lot of stand-up, and there’s usually a credit for the director (who’s not the comedian).

To me it seems like a stand-up comedy set involves coordinating a few different cameras, but how much could a director possibly affect that?

I understand the role of a director for a film, but what does a director of a stand-up comedy set actually do?

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