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In a similar boat.

I got to a point to where I was taking 60 mg of Dexilant twice a day, now down to neximum 20 mg in the morning and 150 mg of ranitidine at night.

I tried to go off the nexium but after 2-3 days had horrible reflux and had to get back on it.

The dr. told me that basically I do need to eventually (sooner than later) ween myself off, which would require strict lifestyle changes, diet changes and working out often. I've gotten better but have fallen back off the wagon and am eating like shit again.

Surgery obviously would be a last resort option but is there. The issue with the medicine is that it doesn't heal the GERD, just helps with symptoms and can heal esophageal damage. But obviously the PPIs have terrible long term effects.

My mom and grandpa both have it too. From what I understand as shitty as the long term effects are it's worth it to take the PPIs instead of developing Barretts and cancer.

Obviously the best case to really get control of your diet, exercise daily and stick to the lifestyle changes (small meals, lots of water, nothing too spicy or fried, nothing late at night, etc.) and slowly ween off.

Wish you the best!

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3 points · 1 day ago

the PPIs have terrible long term effects

This isn't really true.

I hope so, I've just read otherwise, especially risks associated to dementia. Any evidence you can provide?

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Proton pump inhibitor use was not associated with dementia risk, even for people with high cumulative exposure. Although there are other safety concerns with long‐term PPI use, results from our study do not support that these medications should be avoided out of concern about dementia risk.

Source: https://onlinelibrary.wiley.com/doi/full/10.1111/jgs.15073

2 points · 1 day ago

Depends a lot on what is changing, since going from a legacy SQL database to a streaming API is going to be very different regardless.

Assuming that you generally have a 1:1 situation though, the easiest thing is to look at things like univariate distributions and missing data amounts. For me, I would look more at how the data is being consumed, and check that those consumption patterns are producing the same kinds of results with the new source.

3 points · 1 day ago

This was an issue with me for sure, until I got better control over my nighttime reflux.

My recommendations are:

  • Sleep with your upper body inclined (i.e., wedge pilled)
  • Take a small sip of Gaviscon Liquid to coat your throat right before bed
  • Take a Ranitidine (Zantac) right before bed
  • Do not eat or drink anything within 2-3 hours of bed
  • If you have sleep apnea, get a CPAP machine
Original Poster1 point · 2 days ago

What do you mean by IIRC?

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It's an acronym for "If I Recall Correctly."

Original Poster1 point · 2 days ago

That makes sense.. I suppose her sulfur burps stopped after her pregnancy or did they find something causing it?

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They stopped.

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Not to be difficult here but I’d really like to read the material your doctor referred to. Not because I think she’s misleading you but because I’ve been in PPIs for a very long time and could benefit from anything that tells me I’m going to be ok. Sources? Please?!?

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This is up to date and covers most of the risks pretty well:

https://www.uspharmacist.com/article/proton-pump-inhibitors-considerations-with-longterm-use

Basically, the risks are minor and mostly associated with either low acid levels (C. diff infection) or vitamin/mineral deficiencies (fractures from lack of calcium).

There are some studies showing correlations between long term PPI use and a slight increase in the risk of dementia, but nothing conclusive.

3 points · 3 days ago

This doesn't sound like a life or death type of deal, which is really what the ER is for. Call the GI and see if they can get you in earlier. Doctors often leave spots open to fit in "emergency" type appointments.

In the meantime, make sure you are being really strict with your diet. Absolutely no trigger or your own potential trigger foods. For many people, GERD can be completely managed with diet and lifestyle changes.

Also, did your doctor put you both Protonix and Zantac? Typically you'd only take one of those.

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I was on just pantoprazole (Protonix) but was having issues during the night, so my GI doctor added one ranitidine (Zantac) just before bed. They work via different methods, so it isn't a huge deal.

Original Poster1 point · 2 days ago

Do you still take Zantac before bed, or are you better now?

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I still take it before bed, and it has helped a lot. I used to basically wake up feeling like my throat was ripping itself apart, and now I just wake up with a bad taste in my mouth.

This all said, I have a hiatal hernia with my GERD, so even if I eat everything perfectly I still have issues. However, things have gotten about 70-80% better with weight loss, proper diet, proper sleep, and dealing with anxiety/stress.

If I still have bad symptoms after losing all of the weight, I will consider getting surgery to repair the hernia.

This is why it is generally a good idea to start with an strict elimination, then add things back one at a time.

Comment deleted4 days ago
21 points · 4 days ago

No, it makes it simply a premeditated killing. Murder requires the killing to be both premeditated and unlawful.

That said, whether it is just or moral is unrelated to state sanctioning.

Then are state sanctioned death camps not really mass murder but mass executions?

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4 points · 4 days ago

Internally within that state, it is not mass murder. Outside that state, another state might consider such acts illegal (despite not being in their jurisdiction), and would consider it murder.

Moderator of r/datascience, speaking officiallyScore hidden · 4 days ago · Stickied comment
Original Poster1 point · 4 days ago

It's my first time to get sedated. Is there a way for me to find out if I'm allergic to anything in advance?

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2 points · 4 days ago

Not sure, but I don't think you need to worry about that. That kind of allergic reaction is very rare, and assuming you are doing this in a hospital, they will have all the people and drugs needed to quickly deal with any adverse reactions quickly.

As far as I can tell, the only real risks are them making a serious medical error like a tear (3 in 10,000) or the general risks with anesthesia (something like 1 in 100,000).

Original Poster1 point · 4 days ago

...That second paragraph made me pretty nervous.

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3 points · 4 days ago

Those risks are still very rare, to the point where it really isn't worth thinking about them much.

For example, if you live in the US, you have better odds of getting in a car accident on the way to the hospital than dying from an issue with the anesthesia or a medical error during the endoscopy.

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Have you tried Gaviscon liquid antacid?

Otherwise, maybe try something hot like an herbal tea (not immediate, I know)?

Omega037 commented on

My GERD/Hiatal Hernia caused nausea before and after I started taking PPIs, so I generally just chalk it up to that.

Relieving abdominal pressure (losing weight, eating smaller meals, etc) seems to help me the most with that, though reducing anxiety/stress goes a long way too.

Did they actually rule out the more medical common causes that are supported by clinical evidence?

13

Welcome to this week's 'Entering & Transitioning' thread!

This thread is a weekly sticky post meant for any questions about getting started, studying, or transitioning into the data science field.

This includes questions around learning and transitioning such as:

  • Learning resources (e.g., books, tutorials, videos)
  • Traditional education (e.g., schools, degrees, electives)
  • Alternative education (e.g., online courses, bootcamps)
  • Career questions (e.g., resumes, applying, career prospects)
  • Elementary questions (e.g., where to start, what next)

We encourage practicing Data Scientists to visit this thread often and sort by new.

You can find the last thread here:

http://goedhartvoordieren.nl/?page=r/datascience/comments/956n5i/weekly_entering_transitioning_thread_questions/

13
52 comments
4 points · 8 days ago

There is a hodgepodge because unlike Statistics or Computer Science, Data Science is not a well-defined academic field. Thus you don't have any well-defined academic organizations or journals for Data Science.

Whether Data Science should develop into its own academic field (rather than a sub-field of Stats, CS, and others), is the more pressing question. If it does, the rest (rigorous associations, journals, conferences, etc) will follow.

9 points · 9 days ago

Is it worth learning Julia for folks in industry? Even if it performs better than naively written Python, using TensorFlow in Python seems massively better than the Julia alternatives

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Original Poster7 points · 9 days ago

Depends on the kind of work you are doing. The ecosystem is still in the early stages of development, so it wouldn't hurt to wait a while, probably. If you are just looking for a glue language that connects things together or wraps code that was written in a lower level language, then Python is much better at the moment.

The main advantages of the language right now are:

  • There are several specific mathematical/statistical areas where Julia has far better libraries/capabilities than Python at the moment, though usually they are on part with R or Matlab.
  • For numeric computation speed, it is far superior.
  • Handles many types of mathematics natively.
  • Parallelism is very simple to do.
  • Profiling code is very simple to do.
  • Julia code can be transpiled into C.
  • Allows both dynamic and static typing.
  • Related to the above, development in Julia follows a pattern where you can quickly prototype a method, and then later come back and easily make it much faster and safer using things like static typing and multiple dispatch.
  • With less age/ecosystem comes far less legacy issues.
  • While Python has some similar tools, Julia's Interop package group has packages that allow Julia to easily call code written in Python, R, Matlab, Mathematica, Java, C++, and several other languages.
  • Being a new language, many of the developments in software engineering over the past couple of decades have been incorporated in the language from the ground up. Python has had to tack on things later or have 3rd party development to solve a lot of the same issues (e.g., pip, pytest, requests, asyncio, mypy, PyPy).

Considering the extensibility and current community support for R and Python, I think "supplant/replace" is a bit strong. I guess I think of julia as more of a high level complement to the existing data science tools, that could disrupt current commercial offerings, like MATLAB.

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Original Poster13 points · 9 days ago

The language design itself has the functional potential to replace those other languages in most areas, but ultimately it will end up being about ecosystems.

If Julia gets enough adoption, it will get more tooling and good packages around it that make it easier to use as a replacement. However, Matlab, Python and R have a 20-40 year head start with their ecosystems, which is a pretty huge mountain to climb.

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7

Welcome to this week's 'Entering & Transitioning' thread!

This thread is a weekly sticky post meant for any questions about getting started, studying, or transitioning into the data science field.

This includes questions around learning and transitioning such as:

  • Learning resources (e.g., books, tutorials, videos)
  • Traditional education (e.g., schools, degrees, electives)
  • Alternative education (e.g., online courses, bootcamps)
  • Career questions (e.g., resumes, applying, career prospects)
  • Elementary questions (e.g., where to start, what next)

We encourage practicing Data Scientists to visit this thread often and sort by new.

You can find the last thread here:

http://goedhartvoordieren.nl/?page=r/datascience/comments/934oxd/weekly_entering_transitioning_thread_questions/

7
64 comments

Is there a library for this?

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Original Poster1 point · 9 days ago

I'm sure there are a bunch of implementations of collaborative filtering out there, though it is simple enough to implement a basic version yourself. I would focus more on understanding what it is you want to do before trying to throw a random library at it.

I have a irrelevant question, how did you switch from biotech to data scientist?

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Original Poster1 point · 9 days ago

There wasn't really a switch, my first role out of grad school was as a Predictive Analytics Scientist at a biotech company, which later was renamed to Data Scientist along with a few other roles.

As to how I got that role, my grad work was mostly applying machine learning to biomedical applications, so it was a decent fit.

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Omega037 commented on
r/GERDPosted by
Original Poster1 point · 9 days ago

At the time 9 months ago it showed little reflux but since then it has gotten a whole lot worse I've been down every path went on the shitty diet

Nothing has worked I did a gastric emptying scan today results were fine

Tommorow I go for a barium swallow

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I'd maybe hold off on having surgery until you have a better understanding of what the underlying problem is.

You also say you have gone down every path, but are you sure that is true? Simply going on a diet isn't trying everything.

Original Poster1 point · 9 days ago

I've been on every medication on the market I've had so many tests it's not even funny

The last medication left that I'm currently taken is 60mg dexilent twice a day and 300mg of zantac twice a day and it has not worked in 4 months my gi recommended me to a surgeon

And now I have to get 4 more tests done I've been in so much god damn pain for a year now I cant tske it anymore anything or everything I liked has pretty much been stripped or ruined for me

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What were the results of your endoscopy?

A state has to be recognized before it can get sanctioned. The Israeli government prefers eternal war over recognizing Palestine as a state.

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0 points · 9 days ago

That isn't true. ISIL and Al-Qaida aren't recognized states but were sanctioned by the UN Security Council:

https://www.un.org/sc/suborg/en/sanctions/1267/aq_sanctions_list

6 points · 9 days ago

So, as someone that has never really hung out around the bars on Main St at night, I can't tell if all this attention is actually trying to solve a very real problem, or just cantankerous people wanting to abuse what little power they have.

Moderator of r/datascience, speaking officially1 point · 9 days ago

Posting in the Weekly Sticky thread might be a good start...

Spotfire has quite a learning curve for sure, and documentation you can find online isn't always great.

My advice would be to find out what (if any) your company has gotten in the way of training documents/videos/courses along with their licenses.

That said, Spotfire does have a pretty robust set of capabilities (especially if you get into the Data Function and Action Script territory), so long as you can figure out how to use them.

2

So after taking a shower this morning, my wife noticed a small amount of water on the floor of our unfinished basement near the PVC drain pipe. I am not 100% sure exactly where the leak is, but it seems to be pooling on top of this joint, so I assume it is coming from the bottom of the joint above it (the 6-way).

Unfortunately, my plumbing experience is pretty limited, so I wanted to get opinions on how I would go about fixing this?

2
1 comment

3) Resign and leave the country before all his assets are seized and he's tried for treason

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The charges would be something like obstruction, fraud, and/or campaign finance violations, not treason.

Treason has a very limited definition laid out in the Constitution that would require, among other things, for the United States to be in a declared war with Russia and for any treasonous acts to have at least two direct witnesses.

15

Weekly 'Entering & Transitioning' Thread. Questions about getting started and/or progressing towards becoming a Data Scientist go here.

Weekly 'Entering & Transitioning' Thread. Questions about getting started and/or progressing towards becoming a Data Scientist go here.

Welcome to this week's 'Entering & Transitioning' thread!

This thread is a weekly sticky post meant for any questions about getting started, studying, or transitioning into the data science field.

This includes questions around learning and transitioning such as:

  • Learning resources (e.g., books, tutorials, videos)
  • Traditional education (e.g., schools, degrees, electives)
  • Alternative education (e.g., online courses, bootcamps)
  • Career questions (e.g., resumes, applying, career prospects)
  • Elementary questions (e.g., where to start, what next)

We encourage practicing Data Scientists to visit this thread often and sort by new.

You can find the last thread here:

http://goedhartvoordieren.nl/?page=r/datascience/comments/91c2ij/weekly_entering_transitioning_thread_questions/

15
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