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Original Poster1 point · 5 days ago · edited 5 days ago


In bronchiectasis, exacerbations are believed to be triggered by infectious agents, but often no pathogen can be identified. We hypothesized that acute air pollution exposure may be associated with bronchiectasis exacerbations.

We combined a case-crossover design with distributed lag models in an observational record linkage study. Patients were recruited from a specialist bronchiectasis clinic at Ninewells Hospital, Dundee, UK.

We recruited 432 patients with HRCT diagnosed and clinically confirmed bronchiectasis. After excluding days with missing air pollution data, the final model for PM10 was based on 6741 exacerbations from 430 patients and for NO2 it included 6248 exacerbations from 426 patients. For each 10 µg/m3 increase in PM10 and NO2, the risk of having an exacerbation that same day increased significantly by 4.5% (95%CI:0.9–8.3) and 3.2% (95%CI:0.7–5.8) respectively. The overall increase in risk of exacerbation for a 10 μg/m3 increase in air pollutant concentration was 11.2% (95%CI:6.0–16.8) for PM10 and 4.7% (95%CI:0.1–9.5) for NO2. Subanalysis showed significant higher relative risks during spring (PM10 1.198, 95%CI 1.102–1.303;NO2 1.146, 95%CI:1.035–1.268) and summer (PM102.142, 95%CI:1.785–2.570;NO2 1.352, 95%CI:1.140–1.602) when outdoor air pollution exposure would be expected to be highest.

In conclusion, acute air pollution fluctuations are associated with increased exacerbation risk in bronchiectasis.


Wrong abstract. Just saying.

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Original Poster2 points · 5 days ago

Thanks for letting me know. Fixed.

Wow dude, I could give a shit?

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Original Poster0 points · 5 days ago · edited 5 days ago

The issue is I did give a sh-t; without the YouTube history entry or Netflix 'Continue watching' tag vid to show for it.


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