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Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia by eleitl in heredity

[–]eleitl[S] 0 points1 point  (0 children)

Abstract

Higher educational attainment (EA) is negatively associated with schizophrenia (SZ). However, recent studies found a positive genetic correlation between EA and SZ. We investigate possible causes of this counterintuitive finding using genome-wide association study results for EA and SZ (N = 443,581) and a replication cohort (1169 controls; 1067 cases) with deeply phenotyped SZ patients. We find strong genetic dependence between EA and SZ that cannot be explained by chance, linkage disequilibrium, or assortative mating. Instead, several genes seem to have pleiotropic effects on EA and SZ, but without a clear pattern of sign concordance. Using EA as a proxy phenotype, we isolate FOXO6 and SLITRK1 as novel candidate genes for SZ. Our results reveal that current SZ diagnoses aggregate over at least two disease subtypes: one part resembles high intelligence and bipolar disorder (BIP), while the other part is a cognitive disorder that is independent of BIP.

Low-dose Quinine (from tonic water) and improved sleep onset latency by Rhythos in AskDrugNerds

[–]eleitl 0 points1 point  (0 children)

Strange, for me quinine in tonic water has the opposite effect. Also anecdotally.

‘Idiocracy’ Come True: Even Pentagon Says Morons Are Inheriting the Earth by cliffhanger1983 in collapse

[–]eleitl 17 points18 points  (0 children)

Obesity and lowered cognitive abilities go together

As a data point, my wife visiting the US after 20+ years and me 18+ years encountered an unreasonable amount of fat and/or sick people.

The distribution of borderline morons and sharp people also looks rather bimodal.

i need to create a bootable usb in qubes by ikimthi in Qubes

[–]eleitl 0 points1 point  (0 children)

You can right-click on the running guest in the GUI and attack the USB as a block device. Assuming this is Qubes 3.2, no idea about 4.0.

You will need sudo from within the guest to access the device.

Is the progress currently being made in AI unprecedented or have we seen this hype before? by clockworktf2 in ControlProblem

[–]eleitl 4 points5 points  (0 children)

The progress is largely hardware-driven. Because of end of Moore and intrinsic limitations to the current brand of (deep) ML there will be a few more AI winters until we manage to steal enough from biology or figure it out from first principles to have real AI.

Three Factors Could Explain Physician Burnout by eleitl in medicine

[–]eleitl[S] 0 points1 point  (0 children)

Submission statement: the decline trend seems to be accelerating. What are your personal data points? Do you anticipate a death by thousand papercuts or resolution by catharsis?

Further discussion "In just three years, physician burnout increased from 45.5% to 54.4%. New research found that three factors contribute: The doctor-patient relationship has been morphed into an insurance company-client relationship; Feelings of cynicism; and Lack of enthusiasm for work." on /r/science/comments/986alk/in_just_three_years_physician_burnout_increased/

Variants in regulatory elements of PDE4D associate with Major Mental Illness in the Finnish population by eleitl in heredity

[–]eleitl[S] 0 points1 point  (0 children)

Abstract

We have previously reported a replicable association between variants at the PDE4D gene and familial schizophrenia in a Finnish cohort. In order to identify the potential functional mutations alluded to by these previous findings, we sequenced 945kb of the PDE4D genomic locus in 96 individuals, followed by two stages of genotyping across 6,668 individuals from multiple Finnish cohorts for major mental illnesses. We identified 4,570 SNPs across the PDE4D gene, with 380 associated to schizophrenia (p≤0.05). Importantly, two of these variants, rs35278 and rs165940, are located at transcription factor binding sites, and displayed replicable association in the two-stage enlargement of the familial schizophrenia cohort, (combined statistics for rs35278 p=0.0012; OR=1.18, 95% CI 1.06-1.32; and rs165940 p=0.0016; OR=1.27, 95% CI 1.13-1.41). Further analysis using additional cohorts and endophenotypes revealed that rs165940 principally associates within the psychosis (p=0.025, OR=1.18, 95% CI 1.07-1.30) and cognitive domains of major mental illnesses. Specifically, the cognitive domain was a factor score for quantitative neuropsychological endophenotypes related to verbal learning and memory (p=0.0078, β=-0.19). Moreover, expression data from the GTEx database demonstrated that rs165940 significantly correlates with the mRNA expression levels of PDE4D in the cerebellum (p-value=0.04; post-prob=0.9; m-value=1.4), demonstrating a potential functional consequence for this variant. Thus, rs165940 represents the most likely functional variant for major mental illness at the PDE4D locus in the Finnish population, increasing risk broadly to psychotic disorders. Keywords: Schizophrenia; Psychotic disorders; Mood Disorders; PDE4D, Endophenotypes

21st-century modeled permafrost carbon emissions accelerated by abrupt thaw beneath lakes by eleitl in collapsademic

[–]eleitl[S] 0 points1 point  (0 children)

Abstract

Permafrost carbon feedback (PCF) modeling has focused on gradual thaw of near-surface permafrost leading to enhanced carbon dioxide and methane emissions that accelerate global climate warming. These state-of-the-art land models have yet to incorporate deeper, abrupt thaw in the PCF. Here we use model data, supported by field observations, radiocarbon dating, and remote sensing, to show that methane and carbon dioxide emissions from abrupt thaw beneath thermokarst lakes will more than double radiative forcing from circumpolar permafrost-soil carbon fluxes this century. Abrupt thaw lake emissions are similar under moderate and high representative concentration pathways (RCP4.5 and RCP8.5), but their relative contribution to the PCF is much larger under the moderate warming scenario. Abrupt thaw accelerates mobilization of deeply frozen, ancient carbon, increasing 14C-depleted permafrost soil carbon emissions by ~125–190% compared to gradual thaw alone. These findings demonstrate the need to incorporate abrupt thaw processes in earth system models for more comprehensive projection of the PCF this century.